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Results of a recent study showed that biological therapy regimens, such as enbrel etanercept , humira adalimumab , remicade infliximab , simponi golimumab , or cimzia certolizumab , are less cost-effective compared to dmard combination in triple therapy with azulfidine sulfasalazine , plaquenil hydroxychloroquine , and trexall methotrexate in the treatment of rheumatoid arthritis ra .

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although no longer available commercially in the united states, etretinate has been shown to increase methotrexate serum concentrations and cases of hepatotoxicity e.

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stop taking methotrexate if you get diarrhea, or if you get sores in your mouth.

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unexpectedly severe sometimes fatal bone marrow suppression, aplastic anemia and gastrointestinal toxicity have been reported with concomitant administration of methotrexate usually in high dosage along with some nonsteroidal anti-inflammatory drugs nsaids .

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